Review



endurance treadmill exercise capacity test  (Columbus Instruments)


Bioz Verified Symbol Columbus Instruments is a verified supplier
Bioz Manufacturer Symbol Columbus Instruments manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 96
      Buy from Supplier

    Structured Review

    Columbus Instruments endurance treadmill exercise capacity test
    Maternal high‐calorie diet markedly alters muscle fitness function in PolgA offspring mice. (A and B) Body weight (A) and calorie intake (B) in PolgA offspring with/without M‐HFD challenge during pregnancy ( n = 6/group). (C) Relative inguinal white adipose tissue (ingWAT) and epididymal (epi)WAT weights in PolgA offspring (body weight was used for normalization; n = 6/group). (D) Time‐resolved oxygen consumption (left) and carbon dioxide production (right) of 6‐month‐old PolgA offspring born from mothers fed HFD during pregnancy ( n = 6/group). (E) Relative maximal grip strength (body weight was used for normalization) (left) and 10‐repitition <t>endurance</t> grip strength (middle) and area under the curve (AUC) of endurance strength (right) in 6‐month‐old PolgA offspring with/without M‐HFD challenge ( n = 6/group). (F) Total <t>exercise</t> time (left) and distance (right) through cardiorespiratory exercise <t>test</t> in 6‐month‐old PolgA offspring in response to M‐HFD ( n = 6/group). Mean ± SEM, and each dot represents one litter. * p < 0.05, ** p < 0.01 and *** p < 0.001 in WT vs. PolgA mut , and # p < 0.05, ## p < 0.01 and ### p < 0.001 in CD vs. HFD by two‐sided p values by two‐way ANOVA followed by Tukey's test (A–F).
    Endurance Treadmill Exercise Capacity Test, supplied by Columbus Instruments, used in various techniques. Bioz Stars score: 96/100, based on 343 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/endurance treadmill exercise capacity test/product/Columbus Instruments
    Average 96 stars, based on 343 article reviews
    endurance treadmill exercise capacity test - by Bioz Stars, 2026-04
    96/100 stars

    Images

    1) Product Images from "High‐Calorie Diet During Pregnancy Leads to Muscular Fibrosis and Neuromuscular Damage in Offspring Mice"

    Article Title: High‐Calorie Diet During Pregnancy Leads to Muscular Fibrosis and Neuromuscular Damage in Offspring Mice

    Journal: Journal of Cachexia, Sarcopenia and Muscle

    doi: 10.1002/jcsm.70027

    Maternal high‐calorie diet markedly alters muscle fitness function in PolgA offspring mice. (A and B) Body weight (A) and calorie intake (B) in PolgA offspring with/without M‐HFD challenge during pregnancy ( n = 6/group). (C) Relative inguinal white adipose tissue (ingWAT) and epididymal (epi)WAT weights in PolgA offspring (body weight was used for normalization; n = 6/group). (D) Time‐resolved oxygen consumption (left) and carbon dioxide production (right) of 6‐month‐old PolgA offspring born from mothers fed HFD during pregnancy ( n = 6/group). (E) Relative maximal grip strength (body weight was used for normalization) (left) and 10‐repitition endurance grip strength (middle) and area under the curve (AUC) of endurance strength (right) in 6‐month‐old PolgA offspring with/without M‐HFD challenge ( n = 6/group). (F) Total exercise time (left) and distance (right) through cardiorespiratory exercise test in 6‐month‐old PolgA offspring in response to M‐HFD ( n = 6/group). Mean ± SEM, and each dot represents one litter. * p < 0.05, ** p < 0.01 and *** p < 0.001 in WT vs. PolgA mut , and # p < 0.05, ## p < 0.01 and ### p < 0.001 in CD vs. HFD by two‐sided p values by two‐way ANOVA followed by Tukey's test (A–F).
    Figure Legend Snippet: Maternal high‐calorie diet markedly alters muscle fitness function in PolgA offspring mice. (A and B) Body weight (A) and calorie intake (B) in PolgA offspring with/without M‐HFD challenge during pregnancy ( n = 6/group). (C) Relative inguinal white adipose tissue (ingWAT) and epididymal (epi)WAT weights in PolgA offspring (body weight was used for normalization; n = 6/group). (D) Time‐resolved oxygen consumption (left) and carbon dioxide production (right) of 6‐month‐old PolgA offspring born from mothers fed HFD during pregnancy ( n = 6/group). (E) Relative maximal grip strength (body weight was used for normalization) (left) and 10‐repitition endurance grip strength (middle) and area under the curve (AUC) of endurance strength (right) in 6‐month‐old PolgA offspring with/without M‐HFD challenge ( n = 6/group). (F) Total exercise time (left) and distance (right) through cardiorespiratory exercise test in 6‐month‐old PolgA offspring in response to M‐HFD ( n = 6/group). Mean ± SEM, and each dot represents one litter. * p < 0.05, ** p < 0.01 and *** p < 0.001 in WT vs. PolgA mut , and # p < 0.05, ## p < 0.01 and ### p < 0.001 in CD vs. HFD by two‐sided p values by two‐way ANOVA followed by Tukey's test (A–F).

    Techniques Used:



    Similar Products

    endurance treadmill exercise capacity test  (Columbus Instruments)
    96
    Columbus Instruments endurance treadmill exercise capacity test
    Maternal high‐calorie diet markedly alters muscle fitness function in PolgA offspring mice. (A and B) Body weight (A) and calorie intake (B) in PolgA offspring with/without M‐HFD challenge during pregnancy ( n = 6/group). (C) Relative inguinal white adipose tissue (ingWAT) and epididymal (epi)WAT weights in PolgA offspring (body weight was used for normalization; n = 6/group). (D) Time‐resolved oxygen consumption (left) and carbon dioxide production (right) of 6‐month‐old PolgA offspring born from mothers fed HFD during pregnancy ( n = 6/group). (E) Relative maximal grip strength (body weight was used for normalization) (left) and 10‐repitition <t>endurance</t> grip strength (middle) and area under the curve (AUC) of endurance strength (right) in 6‐month‐old PolgA offspring with/without M‐HFD challenge ( n = 6/group). (F) Total <t>exercise</t> time (left) and distance (right) through cardiorespiratory exercise <t>test</t> in 6‐month‐old PolgA offspring in response to M‐HFD ( n = 6/group). Mean ± SEM, and each dot represents one litter. * p < 0.05, ** p < 0.01 and *** p < 0.001 in WT vs. PolgA mut , and # p < 0.05, ## p < 0.01 and ### p < 0.001 in CD vs. HFD by two‐sided p values by two‐way ANOVA followed by Tukey's test (A–F).
    Endurance Treadmill Exercise Capacity Test, supplied by Columbus Instruments, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/endurance treadmill exercise capacity test/product/Columbus Instruments
    Average 96 stars, based on 1 article reviews
    endurance treadmill exercise capacity test - by Bioz Stars, 2026-04
    96/100 stars
    		  Buy from Supplier
    continuous graded exercise treadmill test trackmaster tmx428cp  (Full Vision Inc)
    90
    Full Vision Inc continuous graded exercise treadmill test trackmaster tmx428cp
    Maternal high‐calorie diet markedly alters muscle fitness function in PolgA offspring mice. (A and B) Body weight (A) and calorie intake (B) in PolgA offspring with/without M‐HFD challenge during pregnancy ( n = 6/group). (C) Relative inguinal white adipose tissue (ingWAT) and epididymal (epi)WAT weights in PolgA offspring (body weight was used for normalization; n = 6/group). (D) Time‐resolved oxygen consumption (left) and carbon dioxide production (right) of 6‐month‐old PolgA offspring born from mothers fed HFD during pregnancy ( n = 6/group). (E) Relative maximal grip strength (body weight was used for normalization) (left) and 10‐repitition <t>endurance</t> grip strength (middle) and area under the curve (AUC) of endurance strength (right) in 6‐month‐old PolgA offspring with/without M‐HFD challenge ( n = 6/group). (F) Total <t>exercise</t> time (left) and distance (right) through cardiorespiratory exercise <t>test</t> in 6‐month‐old PolgA offspring in response to M‐HFD ( n = 6/group). Mean ± SEM, and each dot represents one litter. * p < 0.05, ** p < 0.01 and *** p < 0.001 in WT vs. PolgA mut , and # p < 0.05, ## p < 0.01 and ### p < 0.001 in CD vs. HFD by two‐sided p values by two‐way ANOVA followed by Tukey's test (A–F).
    Continuous Graded Exercise Treadmill Test Trackmaster Tmx428cp, supplied by Full Vision Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/continuous graded exercise treadmill test trackmaster tmx428cp/product/Full Vision Inc
    Average 90 stars, based on 1 article reviews
    continuous graded exercise treadmill test trackmaster tmx428cp - by Bioz Stars, 2026-04
    90/100 stars
    		  Buy from Supplier
    cardiopulmonary exercise tests on a parvo medics trueone 2400 machine  (Parvo Medics Inc)
    90
    Parvo Medics Inc cardiopulmonary exercise tests on a parvo medics trueone 2400 machine
    Maternal high‐calorie diet markedly alters muscle fitness function in PolgA offspring mice. (A and B) Body weight (A) and calorie intake (B) in PolgA offspring with/without M‐HFD challenge during pregnancy ( n = 6/group). (C) Relative inguinal white adipose tissue (ingWAT) and epididymal (epi)WAT weights in PolgA offspring (body weight was used for normalization; n = 6/group). (D) Time‐resolved oxygen consumption (left) and carbon dioxide production (right) of 6‐month‐old PolgA offspring born from mothers fed HFD during pregnancy ( n = 6/group). (E) Relative maximal grip strength (body weight was used for normalization) (left) and 10‐repitition <t>endurance</t> grip strength (middle) and area under the curve (AUC) of endurance strength (right) in 6‐month‐old PolgA offspring with/without M‐HFD challenge ( n = 6/group). (F) Total <t>exercise</t> time (left) and distance (right) through cardiorespiratory exercise <t>test</t> in 6‐month‐old PolgA offspring in response to M‐HFD ( n = 6/group). Mean ± SEM, and each dot represents one litter. * p < 0.05, ** p < 0.01 and *** p < 0.001 in WT vs. PolgA mut , and # p < 0.05, ## p < 0.01 and ### p < 0.001 in CD vs. HFD by two‐sided p values by two‐way ANOVA followed by Tukey's test (A–F).
    Cardiopulmonary Exercise Tests On A Parvo Medics Trueone 2400 Machine, supplied by Parvo Medics Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cardiopulmonary exercise tests on a parvo medics trueone 2400 machine/product/Parvo Medics Inc
    Average 90 stars, based on 1 article reviews
    cardiopulmonary exercise tests on a parvo medics trueone 2400 machine - by Bioz Stars, 2026-04
    90/100 stars
    		  Buy from Supplier
    unsupported upper limb exercise test  (RenderX Inc)
    90
    RenderX Inc unsupported upper limb exercise test
    Maternal high‐calorie diet markedly alters muscle fitness function in PolgA offspring mice. (A and B) Body weight (A) and calorie intake (B) in PolgA offspring with/without M‐HFD challenge during pregnancy ( n = 6/group). (C) Relative inguinal white adipose tissue (ingWAT) and epididymal (epi)WAT weights in PolgA offspring (body weight was used for normalization; n = 6/group). (D) Time‐resolved oxygen consumption (left) and carbon dioxide production (right) of 6‐month‐old PolgA offspring born from mothers fed HFD during pregnancy ( n = 6/group). (E) Relative maximal grip strength (body weight was used for normalization) (left) and 10‐repitition <t>endurance</t> grip strength (middle) and area under the curve (AUC) of endurance strength (right) in 6‐month‐old PolgA offspring with/without M‐HFD challenge ( n = 6/group). (F) Total <t>exercise</t> time (left) and distance (right) through cardiorespiratory exercise <t>test</t> in 6‐month‐old PolgA offspring in response to M‐HFD ( n = 6/group). Mean ± SEM, and each dot represents one litter. * p < 0.05, ** p < 0.01 and *** p < 0.001 in WT vs. PolgA mut , and # p < 0.05, ## p < 0.01 and ### p < 0.001 in CD vs. HFD by two‐sided p values by two‐way ANOVA followed by Tukey's test (A–F).
    Unsupported Upper Limb Exercise Test, supplied by RenderX Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/unsupported upper limb exercise test/product/RenderX Inc
    Average 90 stars, based on 1 article reviews
    unsupported upper limb exercise test - by Bioz Stars, 2026-04
    90/100 stars
    		  Buy from Supplier
    cardiopulmonary exercise testing with continuous expired gas analysis parvomedics trueone 2400  (Parvomedics Inc)
    90
    Parvomedics Inc cardiopulmonary exercise testing with continuous expired gas analysis parvomedics trueone 2400
    Maternal high‐calorie diet markedly alters muscle fitness function in PolgA offspring mice. (A and B) Body weight (A) and calorie intake (B) in PolgA offspring with/without M‐HFD challenge during pregnancy ( n = 6/group). (C) Relative inguinal white adipose tissue (ingWAT) and epididymal (epi)WAT weights in PolgA offspring (body weight was used for normalization; n = 6/group). (D) Time‐resolved oxygen consumption (left) and carbon dioxide production (right) of 6‐month‐old PolgA offspring born from mothers fed HFD during pregnancy ( n = 6/group). (E) Relative maximal grip strength (body weight was used for normalization) (left) and 10‐repitition <t>endurance</t> grip strength (middle) and area under the curve (AUC) of endurance strength (right) in 6‐month‐old PolgA offspring with/without M‐HFD challenge ( n = 6/group). (F) Total <t>exercise</t> time (left) and distance (right) through cardiorespiratory exercise <t>test</t> in 6‐month‐old PolgA offspring in response to M‐HFD ( n = 6/group). Mean ± SEM, and each dot represents one litter. * p < 0.05, ** p < 0.01 and *** p < 0.001 in WT vs. PolgA mut , and # p < 0.05, ## p < 0.01 and ### p < 0.001 in CD vs. HFD by two‐sided p values by two‐way ANOVA followed by Tukey's test (A–F).
    Cardiopulmonary Exercise Testing With Continuous Expired Gas Analysis Parvomedics Trueone 2400, supplied by Parvomedics Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cardiopulmonary exercise testing with continuous expired gas analysis parvomedics trueone 2400/product/Parvomedics Inc
    Average 90 stars, based on 1 article reviews
    cardiopulmonary exercise testing with continuous expired gas analysis parvomedics trueone 2400 - by Bioz Stars, 2026-04
    90/100 stars
    		  Buy from Supplier
    acsm's guidelines for exercise testing and prescription  (Wolters Kluwer Health)
    90
    Wolters Kluwer Health acsm's guidelines for exercise testing and prescription
    Maternal high‐calorie diet markedly alters muscle fitness function in PolgA offspring mice. (A and B) Body weight (A) and calorie intake (B) in PolgA offspring with/without M‐HFD challenge during pregnancy ( n = 6/group). (C) Relative inguinal white adipose tissue (ingWAT) and epididymal (epi)WAT weights in PolgA offspring (body weight was used for normalization; n = 6/group). (D) Time‐resolved oxygen consumption (left) and carbon dioxide production (right) of 6‐month‐old PolgA offspring born from mothers fed HFD during pregnancy ( n = 6/group). (E) Relative maximal grip strength (body weight was used for normalization) (left) and 10‐repitition <t>endurance</t> grip strength (middle) and area under the curve (AUC) of endurance strength (right) in 6‐month‐old PolgA offspring with/without M‐HFD challenge ( n = 6/group). (F) Total <t>exercise</t> time (left) and distance (right) through cardiorespiratory exercise <t>test</t> in 6‐month‐old PolgA offspring in response to M‐HFD ( n = 6/group). Mean ± SEM, and each dot represents one litter. * p < 0.05, ** p < 0.01 and *** p < 0.001 in WT vs. PolgA mut , and # p < 0.05, ## p < 0.01 and ### p < 0.001 in CD vs. HFD by two‐sided p values by two‐way ANOVA followed by Tukey's test (A–F).
    Acsm's Guidelines For Exercise Testing And Prescription, supplied by Wolters Kluwer Health, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/acsm's guidelines for exercise testing and prescription/product/Wolters Kluwer Health
    Average 90 stars, based on 1 article reviews
    acsm's guidelines for exercise testing and prescription - by Bioz Stars, 2026-04
    90/100 stars
    		  Buy from Supplier
    non-invasive prenatal testing (nipt) 2021-b exercise  (College of American Pathologists)
    90
    College of American Pathologists non-invasive prenatal testing (nipt) 2021-b exercise
    Maternal high‐calorie diet markedly alters muscle fitness function in PolgA offspring mice. (A and B) Body weight (A) and calorie intake (B) in PolgA offspring with/without M‐HFD challenge during pregnancy ( n = 6/group). (C) Relative inguinal white adipose tissue (ingWAT) and epididymal (epi)WAT weights in PolgA offspring (body weight was used for normalization; n = 6/group). (D) Time‐resolved oxygen consumption (left) and carbon dioxide production (right) of 6‐month‐old PolgA offspring born from mothers fed HFD during pregnancy ( n = 6/group). (E) Relative maximal grip strength (body weight was used for normalization) (left) and 10‐repitition <t>endurance</t> grip strength (middle) and area under the curve (AUC) of endurance strength (right) in 6‐month‐old PolgA offspring with/without M‐HFD challenge ( n = 6/group). (F) Total <t>exercise</t> time (left) and distance (right) through cardiorespiratory exercise <t>test</t> in 6‐month‐old PolgA offspring in response to M‐HFD ( n = 6/group). Mean ± SEM, and each dot represents one litter. * p < 0.05, ** p < 0.01 and *** p < 0.001 in WT vs. PolgA mut , and # p < 0.05, ## p < 0.01 and ### p < 0.001 in CD vs. HFD by two‐sided p values by two‐way ANOVA followed by Tukey's test (A–F).
    Non Invasive Prenatal Testing (Nipt) 2021 B Exercise, supplied by College of American Pathologists, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/non-invasive prenatal testing (nipt) 2021-b exercise/product/College of American Pathologists
    Average 90 stars, based on 1 article reviews
    non-invasive prenatal testing (nipt) 2021-b exercise - by Bioz Stars, 2026-04
    90/100 stars
    		  Buy from Supplier
    vyntus cardiopulmonary exercise testing  (Carefusion)
    90
    Carefusion vyntus cardiopulmonary exercise testing
    Maternal high‐calorie diet markedly alters muscle fitness function in PolgA offspring mice. (A and B) Body weight (A) and calorie intake (B) in PolgA offspring with/without M‐HFD challenge during pregnancy ( n = 6/group). (C) Relative inguinal white adipose tissue (ingWAT) and epididymal (epi)WAT weights in PolgA offspring (body weight was used for normalization; n = 6/group). (D) Time‐resolved oxygen consumption (left) and carbon dioxide production (right) of 6‐month‐old PolgA offspring born from mothers fed HFD during pregnancy ( n = 6/group). (E) Relative maximal grip strength (body weight was used for normalization) (left) and 10‐repitition <t>endurance</t> grip strength (middle) and area under the curve (AUC) of endurance strength (right) in 6‐month‐old PolgA offspring with/without M‐HFD challenge ( n = 6/group). (F) Total <t>exercise</t> time (left) and distance (right) through cardiorespiratory exercise <t>test</t> in 6‐month‐old PolgA offspring in response to M‐HFD ( n = 6/group). Mean ± SEM, and each dot represents one litter. * p < 0.05, ** p < 0.01 and *** p < 0.001 in WT vs. PolgA mut , and # p < 0.05, ## p < 0.01 and ### p < 0.001 in CD vs. HFD by two‐sided p values by two‐way ANOVA followed by Tukey's test (A–F).
    Vyntus Cardiopulmonary Exercise Testing, supplied by Carefusion, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/vyntus cardiopulmonary exercise testing/product/Carefusion
    Average 90 stars, based on 1 article reviews
    vyntus cardiopulmonary exercise testing - by Bioz Stars, 2026-04
    90/100 stars
    		  Buy from Supplier
    exercise test  (Columbus Instruments)
    96
    Columbus Instruments exercise test
    Maternal high‐calorie diet markedly alters muscle fitness function in PolgA offspring mice. (A and B) Body weight (A) and calorie intake (B) in PolgA offspring with/without M‐HFD challenge during pregnancy ( n = 6/group). (C) Relative inguinal white adipose tissue (ingWAT) and epididymal (epi)WAT weights in PolgA offspring (body weight was used for normalization; n = 6/group). (D) Time‐resolved oxygen consumption (left) and carbon dioxide production (right) of 6‐month‐old PolgA offspring born from mothers fed HFD during pregnancy ( n = 6/group). (E) Relative maximal grip strength (body weight was used for normalization) (left) and 10‐repitition <t>endurance</t> grip strength (middle) and area under the curve (AUC) of endurance strength (right) in 6‐month‐old PolgA offspring with/without M‐HFD challenge ( n = 6/group). (F) Total <t>exercise</t> time (left) and distance (right) through cardiorespiratory exercise <t>test</t> in 6‐month‐old PolgA offspring in response to M‐HFD ( n = 6/group). Mean ± SEM, and each dot represents one litter. * p < 0.05, ** p < 0.01 and *** p < 0.001 in WT vs. PolgA mut , and # p < 0.05, ## p < 0.01 and ### p < 0.001 in CD vs. HFD by two‐sided p values by two‐way ANOVA followed by Tukey's test (A–F).
    Exercise Test, supplied by Columbus Instruments, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/exercise test/product/Columbus Instruments
    Average 96 stars, based on 1 article reviews
    exercise test - by Bioz Stars, 2026-04
    96/100 stars
    		  Buy from Supplier

    Image Search Results


    Maternal high‐calorie diet markedly alters muscle fitness function in PolgA offspring mice. (A and B) Body weight (A) and calorie intake (B) in PolgA offspring with/without M‐HFD challenge during pregnancy ( n = 6/group). (C) Relative inguinal white adipose tissue (ingWAT) and epididymal (epi)WAT weights in PolgA offspring (body weight was used for normalization; n = 6/group). (D) Time‐resolved oxygen consumption (left) and carbon dioxide production (right) of 6‐month‐old PolgA offspring born from mothers fed HFD during pregnancy ( n = 6/group). (E) Relative maximal grip strength (body weight was used for normalization) (left) and 10‐repitition endurance grip strength (middle) and area under the curve (AUC) of endurance strength (right) in 6‐month‐old PolgA offspring with/without M‐HFD challenge ( n = 6/group). (F) Total exercise time (left) and distance (right) through cardiorespiratory exercise test in 6‐month‐old PolgA offspring in response to M‐HFD ( n = 6/group). Mean ± SEM, and each dot represents one litter. * p < 0.05, ** p < 0.01 and *** p < 0.001 in WT vs. PolgA mut , and # p < 0.05, ## p < 0.01 and ### p < 0.001 in CD vs. HFD by two‐sided p values by two‐way ANOVA followed by Tukey's test (A–F).

    Journal: Journal of Cachexia, Sarcopenia and Muscle

    Article Title: High‐Calorie Diet During Pregnancy Leads to Muscular Fibrosis and Neuromuscular Damage in Offspring Mice

    doi: 10.1002/jcsm.70027

    Figure Lengend Snippet: Maternal high‐calorie diet markedly alters muscle fitness function in PolgA offspring mice. (A and B) Body weight (A) and calorie intake (B) in PolgA offspring with/without M‐HFD challenge during pregnancy ( n = 6/group). (C) Relative inguinal white adipose tissue (ingWAT) and epididymal (epi)WAT weights in PolgA offspring (body weight was used for normalization; n = 6/group). (D) Time‐resolved oxygen consumption (left) and carbon dioxide production (right) of 6‐month‐old PolgA offspring born from mothers fed HFD during pregnancy ( n = 6/group). (E) Relative maximal grip strength (body weight was used for normalization) (left) and 10‐repitition endurance grip strength (middle) and area under the curve (AUC) of endurance strength (right) in 6‐month‐old PolgA offspring with/without M‐HFD challenge ( n = 6/group). (F) Total exercise time (left) and distance (right) through cardiorespiratory exercise test in 6‐month‐old PolgA offspring in response to M‐HFD ( n = 6/group). Mean ± SEM, and each dot represents one litter. * p < 0.05, ** p < 0.01 and *** p < 0.001 in WT vs. PolgA mut , and # p < 0.05, ## p < 0.01 and ### p < 0.001 in CD vs. HFD by two‐sided p values by two‐way ANOVA followed by Tukey's test (A–F).

    Article Snippet: Endurance treadmill exercise capacity test was determined using a 25° inclined treadmill exercise along with the indirect respiratory metabolic measurements using a treadmill respiratory measurement system (Oxymax fast 4 lane modular treadmill system; Columbus Instruments) according to the manufacturer's protocols and guidelines, as described in our previous studies [ , ].

    Techniques: